Bacteria?derived ferrichrome inhibits tumor progression in sporadic colorectal neoplasms and colitis?associated cancer

Abstract Background Colorectal cancers develop through several pathways, including the adenoma–carcinoma sequence and colitis-associated carcinogenesis. An altered intestinal microflora has been reported to be associated with development progression of colorectal cancer via these pathways. We identified Lactobacillus casei -derived ferrichrome as a mediator bacterial anti-tumor effect cells upregulation DDIT3. In this study, we investigated effects on precancerous conditions sporadic well cancer. Methods SRB MTT assays were performed assess growth inhibition in vitro. Eighteen organoids prepared from biopsy specimens obtained by colonoscopy. AOM-DSS carcinogenesis model xenograft generated for assessment tumor suppressive vivo. Results Ferrichrome inhibited cell vitro vivo models. exerted strong tumor-suppressive that was superior currently available agents, 5-FU cisplatin, both The combination single treatment either drug. confirmed DDIT3 patient-derived adenoma carcinoma. while exhibiting no anti-inflammatory DSS-colitis model, suggesting cells, but not condition, pathway. Conclusions exerts mediated DDIT3, or cisplatin. These results suggest brevis may candidate drug neoplasms.